Axon extension in the fast and slow lanes: substratum-dependent engagement of myosin II functions.

@article{Ketschek2007AxonEI,
  title={Axon extension in the fast and slow lanes: substratum-dependent engagement of myosin II functions.},
  author={Andrea R Ketschek and Steven L. Jones and Gianluca Gallo},
  journal={Developmental neurobiology},
  year={2007},
  volume={67 10},
  pages={1305-20}
}
Axon extension involves the coordinated regulation of the neuronal cytoskeleton. Actin filaments drive protrusion of filopodia and lamellipodia while microtubules invade the growth cone, thereby providing structural support for the nascent axon. Furthermore, in order for axons to extend the growth cone must attach to the substratum. Previous work indicates that myosin II activity inhibits the advance of microtubules into the periphery of growth cones, and myosin II has also been implicated in… CONTINUE READING

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