Axon Termination, Pruning, and Synaptogenesis in the Giant Fiber System of Drosophila melanogaster Is Promoted by Highwire.

@article{Borgen2017AxonTP,
  title={Axon Termination, Pruning, and Synaptogenesis in the Giant Fiber System of Drosophila melanogaster Is Promoted by Highwire.},
  author={Melissa Borgen and Kimberly N. Rowland and Jana H. B{\"o}rner and Brandon Noel Lloyd and Aruna Khan and Rodney K. Murphey},
  journal={Genetics},
  year={2017},
  volume={205 3},
  pages={1229-1245}
}
The ubiquitin ligase Highwire has a conserved role in synapse formation. Here, we show that Highwire coordinates several facets of central synapse formation in the Drosophila melanogaster giant fiber system, including axon termination, axon pruning, and synaptic function. Despite the similarities to the fly neuromuscular junction, the role of Highwire and… CONTINUE READING