Axon Regeneration in Young Adult Mice Lacking Nogo-A/B

@article{Kim2003AxonRI,
  title={Axon Regeneration in Young Adult Mice Lacking Nogo-A/B},
  author={Ji-Eun Kim and Shuxin Li and Tadzia Grandpre and Dike Qiu and Stephen M Strittmatter},
  journal={Neuron},
  year={2003},
  volume={38},
  pages={187-199}
}
After injury, axons of the adult mammalian brain and spinal cord exhibit little regeneration. It has been suggested that axon growth inhibitors, such as myelin-derived Nogo, prevent CNS axon repair. To investigate this hypothesis, we analyzed mice with a nogo mutation that eliminates Nogo-A/B expression. These mice are viable and exhibit normal locomotion. Corticospinal tract tracing reveals no abnormality in uninjured nogo-A/B(-/-) mice. After spinal cord injury, corticospinal axons of young… CONTINUE READING

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