Axon Regeneration in Young Adult Mice Lacking Nogo-A/B

  title={Axon Regeneration in Young Adult Mice Lacking Nogo-A/B},
  author={J. Kim and S. Li and T. Grandpre and D. Qiu and S. Strittmatter},
  • J. Kim, S. Li, +2 authors S. Strittmatter
  • Published 2003
  • Biology, Medicine
  • Neuron
  • After injury, axons of the adult mammalian brain and spinal cord exhibit little regeneration. It has been suggested that axon growth inhibitors, such as myelin-derived Nogo, prevent CNS axon repair. To investigate this hypothesis, we analyzed mice with a nogo mutation that eliminates Nogo-A/B expression. These mice are viable and exhibit normal locomotion. Corticospinal tract tracing reveals no abnormality in uninjured nogo-A/B(-/-) mice. After spinal cord injury, corticospinal axons of young… CONTINUE READING
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