Axon Initial Segment Kv1 Channels Control Axonal Action Potential Waveform and Synaptic Efficacy

@article{Kole2007AxonIS,
  title={Axon Initial Segment Kv1 Channels Control Axonal Action Potential Waveform and Synaptic Efficacy},
  author={Maarten H P Kole and Johannes Jakob Letzkus and Greg J Stuart},
  journal={Neuron},
  year={2007},
  volume={55},
  pages={633-647}
}
Action potentials are binary signals that transmit information via their rate and temporal pattern. In this context, the axon is thought of as a transmission line, devoid of a role in neuronal computation. Here, we show a highly localized role of axonal Kv1 potassium channels in shaping the action potential waveform in the axon initial segment (AIS) of layer 5 pyramidal neurons independent of the soma. Cell-attached recordings revealed a 10-fold increase in Kv1 channel density over the first 50… CONTINUE READING
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