Axl as a potential therapeutic target in cancer: role of Axl in tumor growth, metastasis and angiogenesis

@article{Li2009AxlAA,
  title={Axl as a potential therapeutic target in cancer: role of Axl in tumor growth, metastasis and angiogenesis},
  author={Yunfang Li and Xiaofeng Ye and C Tan and J -A Hongo and Jiping Zha and J Liu and Dara Y Kallop and Mary J. C. Ludlam and Li Chun Pei},
  journal={Oncogene},
  year={2009},
  volume={28},
  pages={3442-3455}
}
Dysregulation of Axl and its ligand growth arrest-specific 6 is implicated in the pathogenesis of several human cancers. In this study, we have used RNAi and monoclonal antibodies to assess further the oncogenic potential of Axl. Here we show that Axl knockdown reduces growth of lung and breast cancer xenograft tumors. Inhibition of Axl expression attenuates breast cancer cell migration and inhibits metastasis to the lung in an orthotopic model, providing the first in vivo evidence that links… CONTINUE READING

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