Axl and growth arrest-specific gene 6 are frequently overexpressed in human gliomas and predict poor prognosis in patients with glioblastoma multiforme.

@article{Hutterer2008AxlAG,
  title={Axl and growth arrest-specific gene 6 are frequently overexpressed in human gliomas and predict poor prognosis in patients with glioblastoma multiforme.},
  author={Markus Hutterer and Pjotr G. Knyazev and Ariane Abate and Markus O Reschke and Hans Maier and Nadia Stefanova and Tatjana Knyazeva and Verena Barbieri and Markus Reindl and Armin Muigg and Herwig Kostron and Guenther Stockhammer and Axel Ullrich},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2008},
  volume={14 1},
  pages={130-8}
}
PURPOSE The receptor tyrosine kinase Axl has recently been identified as a critical element in the invasive properties of glioma cell lines. However, the effect of Axl and its ligand growth arrest--specific gene 6 (Gas6) in human gliomas is still unknown. EXPERIMENTAL DESIGN Axl and Gas6 expression was studied in 42 fresh-frozen and 79 paraffin-embedded glioma specimens by means of reverse transcription-PCR and immunohistochemistry. The prognostic value of Axl and Gas6 expression was… CONTINUE READING

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GliomaNo subtypeNeoplasms
Additionally , Axl / Gas6 coexpression was observed in glioma cells and tumor vessels .
Gas6 were detectable in gliomas of malignancy grades WHO 2 to 4 .
The receptor tyrosine kinase Axl has recently been identified as a critical element in the invasive properties of glioma cell lines .
Axl and growth arrest - specific gene 6 are frequently overexpressed in human gliomas and predict poor prognosis in patients with glioblastoma multiforme .
Axl and growth arrest - specific gene 6 are frequently overexpressed in human gliomas and predict poor prognosis in patients with glioblastoma multiforme .
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