Axiomatic methods, dopamine and reward prediction error.

  title={Axiomatic methods, dopamine and reward prediction error.},
  author={Andrew Caplin and Mark Dean},
  journal={Current opinion in neurobiology},
  volume={18 2},
The phasic firing rate of midbrain dopamine neurons has been shown to respond both to the receipt of rewarding stimuli, and the degree to which such stimuli are anticipated by the recipient. This has led to the hypothesis that these neurons encode reward prediction error (RPE)-the difference between how rewarding an event is, and how rewarding it was expected to be. However, the RPE model is one of a number of competing explanations for dopamine activity that have proved hard to disentangle… CONTINUE READING