Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation.

@article{Rui2004AxinSP,
  title={Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation.},
  author={Yanning Rui and Zhen Xu and Shu-Yong Lin and Qinxi Li and Hongliang Rui and Wen Luo and Hai-Meng Zhou and P Cheung and Zhenguo Wu and Zhiyun Ye and Peng P. Li and Jiahuai Han and Sheng-cai Lin},
  journal={The EMBO journal},
  year={2004},
  volume={23 23},
  pages={4583-94}
}
Axin and p53 are tumor suppressors, controlling cell growth, apoptosis, and development. We show that Axin interacts with homeodomain-interacting protein kinase-2 (HIPK2), which is linked to UV-induced p53-dependent apoptosis by interacting with, and phosphorylating Ser 46 of, p53. In addition to association with p53 via HIPK2, Axin contains a separate domain that directly interacts with p53 at their physiological concentrations. Axin stimulates p53-dependent reporter transcription in 293 cells… CONTINUE READING
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