Axin expression in thymic stromal cells contributes to an age-related increase in thymic adiposity and is associated with reduced thymopoiesis independently of ghrelin signaling.

@article{Yang2009AxinEI,
  title={Axin expression in thymic stromal cells contributes to an age-related increase in thymic adiposity and is associated with reduced thymopoiesis independently of ghrelin signaling.},
  author={Hyunwon Yang and Yun-Hee Youm and Yuxiang Sun and Jong-Seop Rim and Craig J. Galb{\'a}n and Bolormaa Vandanmagsar and Vishwa Deep Dixit},
  journal={Journal of leukocyte biology},
  year={2009},
  volume={85 6},
  pages={928-38}
}
The adipocytes are the predominant cell types that constitute the bulk of the thymic microenvironment by the fifth decade of life in healthy humans. An age-related increase in thymic adiposity is associated with reduced thymopoiesis and compromised immune surveillance in the elderly. However, the mechanisms regulating the generation of intrathymic adipocytes during aging remain to be elucidated. Here, we report that the CD45- thymic stromal cells (TSCs) are amenable to adipogenesis. We… CONTINUE READING

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