Axin, an inhibitor of the Wnt signalling pathway, interacts with β‐catenin, GSK‐3β and APC and reduces the β‐catenin level

@article{Nakamura1998AxinAI,
  title={Axin, an inhibitor of the Wnt signalling pathway, interacts with $\beta$‐catenin, GSK‐3$\beta$ and APC and reduces the $\beta$‐catenin level},
  author={T. Nakamura and Fumihiko Hamada and Takao Ishidate and Kanako Anai and K Kawahara and Kumao Toyoshima and Tetsu Akiyama},
  journal={Genes to Cells},
  year={1998},
  volume={3}
}
The Wnt/Wingless signalling pathway plays an important role in both embryonic development and tumorigenesis. β‐Catenin and Axin are positive and negative effectors of the Wnt signalling pathway, respectively. 
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The data are reviewed to show how Axin regulates multiple signaling pathways by serving as a scaffold protein, controlling diverse cellular functions in proliferation, fate determination, and suppression of tumorigenesis.
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Interaction of Axin and Dvl‐2 proteins regulates Dvl‐2‐stimulated TCF‐dependent transcription
TLDR
The relationship between Axin and Dvl‐2, a member of the Dishevelled family of proteins that function upstream of GSK‐3β, is explored, suggesting a close association between the two proteins, a conclusion supported by co‐immunoprecipitation data.
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References

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TLDR
It is shown that Axin simultaneously binds two components of the Wnt pathway, β-catenin and its negative regulator glycogen synthase kinase-3β, and can block signaling stimulated by Wnt or by adenomatous polyposis coli mutations.
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Control of stability of beta-catenin is central in the wnt signaling pathway. Here, the protein conductin was found to form a complex with both beta-catenin and the tumor suppressor gene product
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TLDR
It is shown that when β-catenin is present in excess, APC binds to another component of the WINGLESS pathway, glycogen synthase kinase 3β (GSK3β), a mammalian homolog of Drosophila ZESTE WHITE 3, which was a good substrate for GSK3β in vitro and the phosphorylation sites were mapped to the central region of APC.
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TLDR
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TLDR
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TLDR
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TLDR
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The human homologue of the Drosophila discs large tumour suppressor protein (hDLG) and closely related proteins such as postsynaptic density protein 95 kDa (PSD‐95) are associated with
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