Axially chiral dicarboxylic acid catalyzed activation of quinone imine ketals: enantioselective arylation of enecarbamates.

Abstract

The synthetic utility of quinone imine ketals in the context of asymmetric catalysis was disclosed for the first time. By expanding the utility of chiral Brønsted acid catalysis to the electrophilic activation of quinone imine ketals, we succeeded in the development of highly enantioselective arylation of encarbamates to give α-amino-β-aryl ethers wherein… (More)
DOI: 10.1021/ja407501h

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