Axial vascularization of a large volume calcium phosphate ceramic bone substitute in the sheep AV loop model.

@article{Beier2010AxialVO,
  title={Axial vascularization of a large volume calcium phosphate ceramic bone substitute in the sheep AV loop model.},
  author={Justus Patrick Beier and Raymund E Horch and A. Hess and Andreas Arkudas and Johanna Heinrich and Johanna S Loew and Heinz Gulle and Elias P. Polykandriotis and Oliver A Bleiziffer and Ulrich Kneser},
  journal={Journal of tissue engineering and regenerative medicine},
  year={2010},
  volume={4 3},
  pages={216-23}
}
Vascularization still remains an obstacle to engineering of bone tissue with clinically relevant dimensions. Our aim was to induce axial vascularization in a large volume of a clinically approved biphasic calcium phosphate ceramic by transferring the arteriovenous (AV) loop approach to a large animal model. HA/beta-TCP granula were mixed with fibrin gel for a total volume of 16 cm(3), followed by incorporation into an isolation chamber together with an AV loop. The chambers were implanted into… CONTINUE READING
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