Axial stem cells deriving both posterior neural and mesodermal tissues during gastrulation.

@article{Kondoh2012AxialSC,
  title={Axial stem cells deriving both posterior neural and mesodermal tissues during gastrulation.},
  author={Hisato Kondoh and Tatsuya Takemoto},
  journal={Current opinion in genetics & development},
  year={2012},
  volume={22 4},
  pages={374-80}
}
The posterior neural plate is primarily derived from the axial stem cells bipotential for neural and paraxial mesodermal development, which reside in the caudal lateral epiblast (CLE) of gastrulating amniote embryos. This process has been demonstrated only recently through cell lineage analyses and determination of Sox2 activation mechanisms. The alternative developmental pathways depend on the activation of either transcription factor genes Sox2 (neural) or Tbx6 (mesodermal); the latter occurs… CONTINUE READING

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