Axial helix rotation as a mechanism for signal regulation inferred from the crystallographic analysis of the E. coli serine chemoreceptor.

@article{Ferris2014AxialHR,
  title={Axial helix rotation as a mechanism for signal regulation inferred from the crystallographic analysis of the E. coli serine chemoreceptor.},
  author={Hedda U. Ferris and Kornelius Zeth and Michael Hulko and Stanislaw Dunin-Horkawicz and Andrei N. Lupas},
  journal={Journal of structural biology},
  year={2014},
  volume={186 3},
  pages={
          349-56
        }
}
Bacterial chemotaxis receptors are elongated homodimeric coiled-coil bundles, which transduce signals generated in an N-terminal sensor domain across 15-20nm to a conserved C-terminal signaling subdomain. This signal transduction regulates the activity of associated kinases, altering the behavior of the flagellar motor and hence cell motility. Signaling is in turn modulated by selective methylation and demethylation of specific glutamate and glutamine residues in an adaptation subdomain. We… CONTINUE READING
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