Axial Hox9 activity establishes the posterior field in the developing forelimb.

  title={Axial Hox9 activity establishes the posterior field in the developing forelimb.},
  author={Ben Xu and Deneen M Wellik},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={108 12},
Current models hold that the early limb field becomes polarized into anterior and posterior domains by the opposing activities of Hand2 and Gli3. This polarization is essential for the initiation of Shh expression in the posterior margin of the limb bud, but how this polarity is established is not clear. Here we show that initial anteroposterior polarization of the early forelimb field requires the function of all four Hox9 paralogs (Hoxa9, Hoxb9, Hoxc9, and Hoxd9). This is unexpected, given… CONTINUE READING
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Distinct roles of Hand2 in initiating polarity and posterior Shh expression during the onset of mouse limb bud development

  • A Galli
  • PLoS Genet
  • 2010

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