Avoidance of nitrous oxide for patients undergoing major surgery: a randomized controlled trial.

@article{Myles2007AvoidanceON,
  title={Avoidance of nitrous oxide for patients undergoing major surgery: a randomized controlled trial.},
  author={Paul S. Myles and Kate Leslie and Matthew T. V. Chan and Andrew Forbes and Michael James Paech and Philip J Peyton and Brendan S. Silbert and Elaine Pascoe},
  journal={Anesthesiology},
  year={2007},
  volume={107 2},
  pages={
          221-31
        }
}
BACKGROUND Nitrous oxide is widely used in anesthesia, often administered at an inspired concentration around 70%. Although nitrous oxide interferes with vitamin B12, folate metabolism, and deoxyribonucleic acid synthesis and prevents the use of high inspired oxygen concentrations, the consequences of these effects are unclear. METHODS Patients having major surgery expected to last at least 2 h were randomly assigned to nitrous oxide-free (80% oxygen, 20% nitrogen) or nitrous oxide-based (70… CONTINUE READING

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