Avoidance of iron toxicity through regulation of bacterial iron transport.

@article{Braun1997AvoidanceOI,
  title={Avoidance of iron toxicity through regulation of bacterial iron transport.},
  author={Volkmar Braun},
  journal={Biological chemistry},
  year={1997},
  volume={378 8},
  pages={779-86}
}
Under oxic conditions and at pH 7, ferric iron is insoluble, and complex formation of Fe3+ with ligands is required to supply cells with iron. Bacteria and fungi synthesize and secrete low-molecular-weight compounds, termed siderophores, that bind Fe3+. Certain human pathogens take up iron from human transferrin, lactoferrin, hemoglobin, and heme. The… CONTINUE READING