Avoidance of apoptosis as a mechanism of drug resistance.

@article{Dive1997AvoidanceOA,
  title={Avoidance of apoptosis as a mechanism of drug resistance.},
  author={Caroline Dive},
  journal={Journal of internal medicine. Supplement},
  year={1997},
  volume={740},
  pages={139-45}
}
  • Caroline Dive
  • Published 1997 in Journal of internal medicine. Supplement
Inherent or acquired drug resistance is a major obstacle for the successful treatment of cancers. Many mechanisms of drug resistance have been described including a decreased drug uptake, an increase in DNA damage repair, enhanced drug detoxification, an altered level or mutation of the intracellular drug target or an increased drug efflux from the cell. Most of these mechanisms impinge upon the interaction of a drug with its cellular target or immediate consequences of such as interaction. For… CONTINUE READING
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