Avoid mitochondrion-toxic antiepileptic drugs in glycine encephalopathy.

We read with interest the article by Khraim et al. about 3 Palestinian siblings from consanguineous parents with glycine encephalopathy(GCE), also known as non-ketonic hyperglycinemia(NKH), due to a mutation in the GLDC gene [1]. We have the following comments and concerns. Patient-1 received phenytoin for seizures at age 6 months after valproic-acid had… CONTINUE READING