Avocado/soybean unsaponifiables increase aggrecan synthesis and reduce catabolic and proinflammatory mediator production by human osteoarthritic chondrocytes.

@article{Henrotin2003AvocadosoybeanUI,
  title={Avocado/soybean unsaponifiables increase aggrecan synthesis and reduce catabolic and proinflammatory mediator production by human osteoarthritic chondrocytes.},
  author={Yves Edgard Henrotin and Christelle Sanchez and Michelle A Deberg and Nathalie Piccardi and Georges Bernard Guillou and Philippe Msika and J. -Y. L. Reginster},
  journal={The Journal of rheumatology},
  year={2003},
  volume={30 8},
  pages={1825-34}
}
OBJECTIVE To investigate the effects of avocado (A)/soybean (S) unsaponifiables on the metabolism of human osteoarthritic (OA) chondrocytes cultured in alginate beads over 12 days. METHODS Enzymatically isolated OA chondrocytes were cultured in alginate beads in a well defined culture medium for 12 days, in the presence or not of 10-10 M interleukin 1beta (IL-1beta). DNA content was measured using a fluorometric method. Production of aggrecan (AGG), stromelysin-1 (MMP-3), tissue inhibitor of… CONTINUE READING

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