Avidity for antigen shapes clonal dominance in CD8+ T cell populations specific for persistent DNA viruses

Abstract

The forces that govern clonal selection during the genesis and maintenance of specific T cell responses are complex, but amenable to decryption by interrogation of constituent clonotypes within the antigen-experienced T cell pools. Here, we used point-mutated peptide-major histocompatibility complex class I (pMHCI) antigens, unbiased TCRB gene usage… (More)

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Cite this paper

@article{Price2005AvidityFA, title={Avidity for antigen shapes clonal dominance in CD8+ T cell populations specific for persistent DNA viruses}, author={David A. Price and Jason M. Brenchley and Laura Ruff and Michael R Betts and Brenna J. Hill and Mario Roederer and Richard A. Koup and Steven A. Migueles and Emma Gostick and Linda Wooldridge and Andrew K Sewell and Mark Connors and Daniel C. Douek}, journal={The Journal of Experimental Medicine}, year={2005}, volume={202}, pages={1349 - 1361} }