Avidin as a model for charge driven transport into cartilage and drug delivery for treating early stage post-traumatic osteoarthritis.

Abstract

Local drug delivery into cartilage remains a challenge due to its dense extracellular matrix of negatively charged proteoglycans enmeshed within a collagen fibril network. The high negative fixed charge density of cartilage offers the unique opportunity to utilize electrostatic interactions to augment transport, binding and retention of drug carriers. With… (More)
DOI: 10.1016/j.biomaterials.2013.09.091

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Cite this paper

@article{Bajpayee2014AvidinAA, title={Avidin as a model for charge driven transport into cartilage and drug delivery for treating early stage post-traumatic osteoarthritis.}, author={Ambika Goel Bajpayee and Cliff R. Wong and Moungi G Bawendi and Eliot H. Frank and Alan J. Grodzinsky}, journal={Biomaterials}, year={2014}, volume={35 1}, pages={538-49} }