Avian-virus-like receptor specificity of the hemagglutinin impedes influenza virus replication in cultures of human airway epithelium.

@article{Matrosovich2007AvianviruslikeRS,
  title={Avian-virus-like receptor specificity of the hemagglutinin impedes influenza virus replication in cultures of human airway epithelium.},
  author={Mikhail Matrosovich and Tatyana Y Matrosovich and Jennifer Uhlendorff and Wolfgang Garten and H -D Klenk},
  journal={Virology},
  year={2007},
  volume={361 2},
  pages={384-90}
}
A non-optimal receptor-binding specificity of avian influenza viruses is believed to hamper their replication in humans; however, the magnitude of this restriction remains undefined. Here we generated recombinant viruses, R1 and R2, that differed solely by two amino acids in the receptor-binding site of their hemagglutinin (HA). R1 harbored the original HA of the pandemic human virus A/Hong Kong/1/68 (H3N2), whereas R2 was the L226Q/S228G HA mutant with avian-virus-like receptor specificity. In… CONTINUE READING
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