Avian precardiac endoderm/mesoderm induces cardiac myocyte differentiation in murine embryonic stem cells.

The ability to regenerate damaged myocardium with tissue derived from embryonic stem (ES) cells is currently undergoing extensive investigation. As a prerequisite to transplantation therapy, strategies must be developed to induce ES cells to the cardiac phenotype. Toward this end, cues from mechanisms of embryonic induction have been exploited, based on… CONTINUE READING