Avian influenza A virus PB2 promotes interferon type I inducing properties of a swine strain in porcine dendritic cells.

@article{OcaaMacchi2012AvianIA,
  title={Avian influenza A virus PB2 promotes interferon type I inducing properties of a swine strain in porcine dendritic cells.},
  author={Manuela Oca{\~n}a-Macchi and Meret Elisabeth Ricklin and Sylvie Python and Gsell-Albert Monika and J{\"u}rgen Stech and Olga Stech and Artur Summerfield},
  journal={Virology},
  year={2012},
  volume={427 1},
  pages={1-9}
}
The 2009 influenza A virus (IAV) pandemic resulted from reassortment of avian, human and swine strains probably in pigs. To elucidate the role of viral genes in host adaptation regarding innate immune responses, we focussed on the effect of genes from an avian H5N1 and a porcine H1N1 IAV on infectivity and activation of porcine GM-CSF-induced dendritic cells (DC). The highest interferon type I responses were achieved by the porcine virus reassortant containing the avian polymerase gene PB2… CONTINUE READING