Avian flu: Influenza virus receptors in the human airway

  title={Avian flu: Influenza virus receptors in the human airway},
  author={K. Shinya and M. Ebina and S. Yamada and M. Ono and N. Kasai and Y. Kawaoka},
  • K. Shinya, M. Ebina, +3 authors Y. Kawaoka
  • Published 2006
  • Biology, Medicine
  • Nature
  • Although more than 100 people have been infected by H5N1 influenza A viruses, human-to-human transmission is rare. What are the molecular barriers limiting human-to-human transmission? Here we demonstrate an anatomical difference in the distribution in the human airway of the different binding molecules preferred by the avian and human influenza viruses. The respective molecules are sialic acid linked to galactose by an α-2,3 linkage (SAα2,3Gal) and by an α-2,6 linkage (SAα2,6Gal). Our findings… CONTINUE READING

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