Avian and Canine Aldehyde Oxidases

@article{Terao2006AvianAC,
  title={Avian and Canine Aldehyde Oxidases},
  author={M. Terao and M. Kurosaki and M. M. Barzago and E. Varasano and Andrea Boldetti and A. Bastone and M. Fratelli and E. Garattini},
  journal={Journal of Biological Chemistry},
  year={2006},
  volume={281},
  pages={19748 - 19761}
}
Aldehyde oxidases are molybdo-flavoenzymes structurally related to xanthine oxidoreductase. They catalyze the oxidation of aldehydes or N-heterocycles of physiological, pharmacological, and toxicological relevance. Rodents are characterized by four aldehyde oxidases as follows: AOX1 and aldehyde oxidase homologs 1-3 (AOH1, AOH2, and AOH3). Humans synthesize a single functional aldehyde oxidase, AOX1. Here we define the structure and the characteristics of the aldehyde oxidase genes and proteins… Expand
Structure and function of mammalian aldehyde oxidases
TLDR
An overview and a discussion of the current knowledge on mammalian AOX isoenzymes are provided. Expand
The mammalian aldehyde oxidase gene family
TLDR
The present paper provides an update of the available information on the evolutionary history, tissue- and cell-specific distribution and function of mammalian aldehyde oxidases. Expand
Structure and evolution of vertebrate aldehyde oxidases: from gene duplication to gene suppression
TLDR
This work cloned the cDNAs encoding the AOX proteins of guinea pig and cynomolgus monkeys, two unique species as to the evolution of this enzyme family, and identifies chimeric RNAs from the human AOX3 and AOx3L1 pseudogenes with potential to encode a novel microRNA. Expand
Characterization and Crystallization of Mouse Aldehyde Oxidase 3: From Mouse Liver to Escherichia coli Heterologous Protein Expression
TLDR
The AOX homolog from mouse liver (mAOX3) was purified and a system for the heterologous expression of mAOX3 in Escherichia coli was established and Spectroscopic characterization showed that FeSII is not assembled completely in mAox3. Expand
Xanthine Oxidoreductase and Aldehyde Oxidases
TLDR
This chapter provides an overview of the current knowledge on the structure, evolution, and function of these highly complex enzymes and identifies various mammalian AOX isoenzymes. Expand
The role of aldehyde oxidase in drug metabolism
TLDR
There is evidence for an increasing relevance of AOX1 in the metabolism and clearance of new drugs, as measures aiming at controlling CYP450-dependent metabolism of prospective therapeutic agents are becoming routine. Expand
Mammalian aldehyde oxidases: genetics, evolution and biochemistry
TLDR
An overview of the current knowledge of genetics, evolution, structure, enzymology, tissue distribution and regulation of mammalian aldehyde oxidases is provided. Expand
Direct comparison of the four aldehyde oxidase enzymes present in mouse gives insight into their substrate specificities
TLDR
A direct and simultaneous comparison of the enzymatic properties and characteristics of the four enzymes on a larger number of substrates has never been performed, and thirty different structurally related aromatic, aliphatic and N-heterocyclic compounds were used as substrates and the kinetic parameters of all four AOX enzymes were directly compared. Expand
The First Mammalian Aldehyde Oxidase Crystal Structure
TLDR
The mouse liver aldehyde oxidase 3 three-dimensional structure combined with kinetic, mutagenesis data, molecular docking, and molecular dynamics studies make a decisive contribution to understand the molecular basis of its rather broad substrate specificity. Expand
Xanthine Oxidoreductase and Aldehyde Oxidase
Aldehyde oxidase (AO) and xanthine oxidoreductase (XOR) are closely related enzymes with very similar primary structures comprising two identical subunits each of which contains four redox centers:Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 67 REFERENCES
The Aldehyde Oxidase Gene Cluster in Mice and Rats
TLDR
The identification, in both mice and rats, of a novel molybdo-flavoenzyme, AOH3, which possesses aldehyde oxidase activity and oxidizes, albeit with low efficiency, exogenous substrates that are recognized by AOH1 and AOX1. Expand
Regulation and Biochemistry of Mouse Molybdo-flavoenzymes
TLDR
It is demonstrated that CD-1, C57BL/6, 129/Sv, and other mouse strains synthesize high levels of AOH1 in the liver and AOH2 in the skin, and that neither enzyme is involved in the in vivo biotransformation of acetaldehyde. Expand
Purification of the Aldehyde Oxidase Homolog 1 (AOH1) Protein and Cloning of the AOH1 and Aldehyde Oxidase Homolog 2 (AOH2) Genes
TLDR
Conservation in the position of exon/intron junctions among the mouse AOH1, AOH2, aldehyde oxidase, and xanthine oxidoreductase loci indicates that these genes are derived from the duplication of an ancestral precursor. Expand
Identification of aldehyde oxidase 1 and aldehyde oxidase homologue 1 as dioxin-inducible genes.
TLDR
Aldehyde oxidases are a family of highly related molybdo-flavoenzymes acting upon a variety of compounds of industrial and medical importance and aOX1/AOH1 activity was shown to be induced by dioxin in mouse liver, confirming that the enzymatic activity was attributable to AOX1. Expand
TAO1, a Representative of the Molybdenum Cofactor Containing Hydroxylases from Tomato*
TLDR
A new gene from tomato is described, which shows the characteristics of a MoCo containing hydroxylase and shares sequence homology with xanthine dehydrogenases and aldehyde oxidases from various organisms, and is likely to encode an alde Hyde oxidase-type activity. Expand
Cloning of the cDNAs Coding for Two Novel Molybdo-flavoproteins Showing High Similarity with Aldehyde Oxidase and Xanthine Oxidoreductase*
TLDR
The cDNAs coding for two novel mouse molybdo-flavoproteins, AOH1 and AOH2 (aldehydeoxidase homolog 1 and 2), were isolated and the AOH 1 protein has benzaldehyde oxidizing activity with electrophoretic characteristics identical to those of a previously identified aldehyde oxidase isoenzyme. Expand
Mammalian molybdo-flavoenzymes, an expanding family of proteins: structure, genetics, regulation, function and pathophysiology.
TLDR
Current knowledge on the structure, enzymology, genetics, regulation and pathophysiology of mammalian molybdo-flavoenzymes is summarized. Expand
Phylogeny and correlations of aldehyde oxidase, xanthine oxidase, xanthine dehydrogenase and peroxidase in animal tissues.
TLDR
Peroxidase was present in all vertebrates and in those invertebrates that burrow in soil and detritus and aldehyde oxidase was widely distributed among molluscs, crustaceans, insects and alll the vertebrate classes except birds. Expand
Role of aldehyde oxidase in biogenic amine metabolism.
TLDR
The results obtained with both in vivo and in vitro inhibitors indicate that aldehyde oxidase plays a major role in homovanillic (HV) and 5-hydroxytryptamine (5-HT) metabolism in guinea pig liver. Expand
Eukaryotic aldehyde dehydrogenase (ALDH) genes: human polymorphisms, and recommended nomenclature based on divergent evolution and chromosomal mapping.
TLDR
A standardized gene nomenclature system is proposed here, based on divergent evolution, using multiple alignment analysis of all 86 eukaryotic aldehyde dehydrogenase (ALDH) amino-acid sequences known at this time. Expand
...
1
2
3
4
5
...