Avian and 1918 Spanish influenza a virus NS1 proteins bind to Crk/CrkL Src homology 3 domains to activate host cell signaling.

@article{Heikkinen2008AvianA1,
  title={Avian and 1918 Spanish influenza a virus NS1 proteins bind to Crk/CrkL Src homology 3 domains to activate host cell signaling.},
  author={Leena S Heikkinen and Arūnas Kazlauskas and Krister M{\'e}len and Ralf Wagner and Thedi Ziegler and Ilkka Julkunen and Kalle Saksela},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 9},
  pages={
          5719-27
        }
}
NS1 (nonstructural protein 1) is an important virulence factor of the influenza A virus. We observed that NS1 proteins of the 1918 pandemic virus (A/Brevig Mission/1/18) and many avian influenza A viruses contain a consensus Src homology 3 (SH3) domain-binding motif. Screening of a comprehensive human SH3 phage library revealed the N-terminal SH3 of Crk and CrkL as the preferred binding partners. Studies with recombinant proteins confirmed avid binding of NS1 proteins of the 1918 virus and a… CONTINUE READING
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The multifunctional NS1 protein of influenza A viruses.

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