Avian adenovirus vector CELO-TK displays anticancer activity in human cancer cells and suppresses established murine melanoma tumors

@article{Shashkova2005AvianAV,
  title={Avian adenovirus vector CELO-TK displays anticancer activity in human cancer cells and suppresses established murine melanoma tumors},
  author={Elena V. Shashkova and Lubov V Cherenova and Dmitry B Kazansky and Konstantin Doronin},
  journal={Cancer Gene Therapy},
  year={2005},
  volume={12},
  pages={617-626}
}
Avian adenovirus CELO is a novel adenovirus vector system with the advantages of efficient production, high virion stability, and the absence of crossreactivity with Ad5-neutralizing antibodies. In this study, we evaluated the anticancer efficacy of a CELO vector encoding the herpes simplex virus type 1 thymidine kinase, a prodrug-activating therapeutic gene. Vectors carrying the gene for HSV-tk or EGFP under the control of the HCMV promoter in place of the “nonessential” region of the CELO… CONTINUE READING

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Kandachi K. China approves first gene therapy

  • S Pearson, H Jia
  • Nat Biotechnol
  • 2004
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