Avian B cell development: lessons from transgenic models.

  title={Avian B cell development: lessons from transgenic models.},
  author={Camil Elie Sayegh and Mira A Rao and Michael Ratcliffe},
  journal={Veterinary immunology and immunopathology},
  volume={72 1-2},
The bursa of Fabricius is critical for the development of B lymphocytes in avian species. Despite considerable advances in our understanding of the molecular mechanisms by which avian antibody diversity is generated, many stages of B-cell development in the bursa and the means by which they are regulated remain unclear. Here we discuss the use of productive chicken retroviral vectors which allow gene transfer in vitro or in vivo as tools to probe the requirements for bursal B-cell development… CONTINUE READING