Avian B-cell development: generation of an immunoglobulin repertoire by gene conversion.

@article{Mccormack1991AvianBD,
  title={Avian B-cell development: generation of an immunoglobulin repertoire by gene conversion.},
  author={W T Mccormack and L W Tjoelker and Craig B Thompson},
  journal={Annual review of immunology},
  year={1991},
  volume={9},
  pages={219-41}
}
The vertebrate B-cell repertoire is capable of generating up to 10(9) different antibody molecules using relatively few germline immunoglobulin (Ig) gene segments. To generate diversity, humans and mice depend on combinatorial and junctional variations that occur during the gene rearrangement events that produce complete heavy and light chain Ig genes. This gene rearrangement process goes on continuously in the bone marrow, where each developing B cell assembles a unique heavy and light chain… CONTINUE READING