Averting transmission: A pivotal target to manage amoebiasis.

  title={Averting transmission: A pivotal target to manage amoebiasis.},
  author={Aadish Rawat and Parikshit Singh and Anupam Jyoti and Sanket Kaushik and Vijay Kumar Srivastava},
  journal={Chemical biology \& drug design},
Amoebiasis is a parasitic infectious disease caused by the enteric protozoan Entamoeba histolytica, a leading basis of deaths accounted to parasites, succeeding malaria and schistosomiasis. Conventional treatment methodologies used to deal with amoebiasis mainly rely on the administration of anti-amoebic compounds and vaccines but are often linked with substantial side-effects on the patient. Besides, cases of development of drug resistance in protozoans have been recorded, contributing further… 

Probing the Peculiarity of EhRabX10, a pseudoRab GTPase, from the Enteric Parasite Entamoeba histolytica through In Silico Modeling and Docking Studies

This in silico study provides an introduction to the characterization of the atypical EhRabX10 and set the stage for future explorations into the mechanisms of nucleotide recognition, binding, and hydrolysis employed by the pseudoEhRab GTPase family.

The flip side of reactive oxygen species in the tropical disease‐Amoebiasis

Insight is given into a solution that could be a potent source in generating new treatment and vaccines for amoebiasis by targeting parasite development and why NOX inhibitors, a potent antiparasitic drug, is not effective for in vivo purposes.

Exploring insights of syntaxin superfamily proteins from Entamoeba histolytica: a prospective simulation, protein‐protein interaction, and docking study

This work characterize the syntaxin 1 like molecule and VAMP from Eh through physiochemical profiling, modeling, atomistic simulation, protein‐protein interaction, and docking approaches on the proteins containing SNARE and synaptobrevin domain to provide better structural and functional insights into these proteins.

Sialic Acids as Receptors for Pathogens

It is predicted that a better understanding of the role of Sias in disease vectors would lead to more effective clinical interventions, and data suggesting the CMAH gene was probably present in the ancestor of animals, shedding light on its glycobiology is presented.


Rida ® Quick Entamoeba test proved to be simple, rapid, convenient, sensitive and specific assay to diagnose E. histolytica / dispar infection for ep-idemiology.

Amoebiasis, cryptosporidiosis and giardiasis

The author discusses the clinical features, diagnosis and management of those more likely to be encountered by doctors in temperate zones, including protozoa known to cause bowel disease in humans.



Entamoeba Encystation: New Targets to Prevent the Transmission of Amebiasis

Developing novel strategies to control encystation and excystation will potentially lead to new measures to block the transmission of amebiasis by interrupting the life cycle of the causative agent.

Cellular and molecular mechanisms that underlie Entamoeba histolytica pathogenesis: prospects for intervention.

This review focuses on components of the molecular machinery that govern these cellular processes and their role in virulence, and discusses how an understanding of this might reveal opportunities to interfere with E. histolytica infection.

Immune Evasion Mechanisms of Entamoeba histolytica: Progression to Disease

This review focuses on the immune evasion mechanisms that Eh uses to survive and induce disease manifestation in the host and identifies several mechanisms that might play critical roles in immune evasion.

Effects of Miltefosine and Other Alkylphosphocholines on Human Intestinal ParasiteEntamoeba histolytica

Liposomal formulations of oleyl- PC or closely related alkyl-PCs could be promising candidates for testing as broad-spectrum antiprotozoal and antitumor agents in humans.

Crosstalk between Entamoeba histolytica and the human intestinal tract during amoebiasis

This research demonstrated that virulent parasites with an invasive phenotype display rapid, highly specific changes in their transcriptome (notably for essential factors involved in carbohydrate metabolism and the processing of glycosylated residues) and combined activation of parasite and host lytic enzymes leads to the destruction of the intestinal parenchyma.

An ex-vivo Human Intestinal Model to Study Entamoeba histolytica Pathogenesis

An ex vivo human colon model to study the early steps in amoebiasis established that E. histolytica caused the removal of the protective mucus coat during the first two hours of incubation, detached the enterocytes, and then penetrated into the lamina propria by following the crypts of Lieberkühn.

Molecular epidemiology, evolution, and phylogeny of Entamoeba spp.

Amoeboid movement in protozoan pathogens.