Aversive properties of opiate receptor blockade: evidence for exclusively central mediation in naive and morphine-dependent rats.

@article{Hand1988AversivePO,
  title={Aversive properties of opiate receptor blockade: evidence for exclusively central mediation in naive and morphine-dependent rats.},
  author={Timothy H. Hand and George F. Koob and Luis Stinus and Michel Le Moal},
  journal={Brain research},
  year={1988},
  volume={474 2},
  pages={364-8}
}
The motivational effects of exclusively peripheral or central opiate receptor blockade were studied using place conditioning. Place aversions were observed with intraventricular (i.c.v.) methylnaloxone (MN) in both naive (200-1000 ng) and morphine-dependent rats (50-500 ng). Subcutaneous MN (0.03-10 mg/kg) was ineffective in naive rats; in dependent rats a small aversion was seen at the highest dose. Place aversions were not necessarily associated with behavioral signs of withdrawal. The data… CONTINUE READING