Aversive olfactory learning and associative long-term memory in Caenorhabditis elegans.

  title={Aversive olfactory learning and associative long-term memory in Caenorhabditis elegans.},
  author={Hisayuki Amano and Ichiro N. Maruyama},
  journal={Learning & memory},
  volume={18 10},
The nematode Caenorhabditis elegans (C. elegans) adult hermaphrodite has 302 invariant neurons and is suited for cellular and molecular studies on complex behaviors including learning and memory. Here, we have developed protocols for classical conditioning of worms with 1-propanol, as a conditioned stimulus (CS), and hydrochloride (HCl) (pH 4.0), as an unconditioned stimulus (US). Before the conditioning, worms were attracted to 1-propanol and avoided HCl in chemotaxis assay. In contrast, after… CONTINUE READING
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