Aversive and appetitive properties of anxiogenic and anxiolytic agents.

  • S. E. File
  • Published 1986 in Behavioural brain research


The place-conditioning paradigm was used to assess the appetitive or aversive nature of anxiolytic and anxiogenic drugs. Rats were given a pre-conditioning preference test in which the time that they spent on each side of a two-compartment chamber was measured; each side was visually distinct. On two days they were confined to one side immediately after… (More)