Aversive and Appetitive Events Evoke the Release of Corticotropin-Releasing Hormone and Bombesin-Like Peptides at the Central Nucleus of the Amygdala

@article{Merali1998AversiveAA,
  title={Aversive and Appetitive Events Evoke the Release of Corticotropin-Releasing Hormone and Bombesin-Like Peptides at the Central Nucleus of the Amygdala},
  author={Zul Merali and Judy F. McIntosh and Pam Kent and David Michaud and Hymie Anisman},
  journal={The Journal of Neuroscience},
  year={1998},
  volume={18},
  pages={4758 - 4766}
}
There is wide agreement that corticotropin-releasing hormone (CRH) systems within the brain are activated by stressful stimuli. There is also mounting evidence for the role of bombesin (BN)-like peptides in the mediation of the stress response. To date, however, the extent to which other stimuli increase the activity of these peptidergic systems has received little attention. In the present investigation we validated and used in vivo microdialysis sampling followed by ex vivo radioimmunoassays… Expand
Impact of repeated stressor exposure on the release of corticotropin-releasing hormone, arginine-vasopressin and bombesin-like peptides at the anterior pituitary
TLDR
The sustained peptidergic alterations observed in the chronically stressed rats may have implications for the development of these stressor-related disorders. Expand
In vivo levels of corticotropin-releasing hormone and gastrin-releasing peptide at the basolateral amygdala and medial prefrontal cortex in response to conditioned fear in the rat
TLDR
It appears that at the BLA, the release of CRH and GRP is related to fear, and the release was significantly correlated with freezing levels such that animals that had higher levels of freezing also had higher interstitial peptide levels. Expand
Differential impact of predator or immobilization stressors on central corticotropin-releasing hormone and bombesin-like peptides in Fast and Slow seizing rat
TLDR
Two lines of rats selectively bred for amygdala excitability show differential endocrinological and neurochemical response patterns to these stressors, and are demonstrated to exhibit differences in tests of anxiety. Expand
The role of neuropeptide Y in the amygdala on corticotropin-releasing factor receptor-mediated behavioral stress responses in the rat
TLDR
Results showed that injections of NPY into the BLA prior to Ucn significantly blocked the development of the avoidance behavior in the two floor choice test and the decrease in SI time that is usually seen following restraint stress, providing further support that an interaction between NPY and CRF within theBLA may be critical for maintaining a normal homeostatic emotional state. Expand
Central Bombesin Activates the Hypothalamic-Pituitary-Adrenal Axis
TLDR
Results suggest that BN-like peptides may regulate certain hypothalamic and extrahypothalamic circuits, including the HPA axis, by affecting regional utilization of ir-CRH and ir-AVP, and/or by provoking the release of these peptides at the Me/Arc, thus increasing their availability downstream at the anterior pituitary and increasing circulating ACTH and corticosterone levels. Expand
Effects of corticosterone on corticotrophin‐releasing hormone and gastrin‐releasing peptide release in response to an aversive stimulus in two regions of the forebrain (central nucleus of the amygdala and prefrontal cortex)
TLDR
It is found that, at both regions, the airpuff‐induced CRH and GRP release were enhanced in the corticosterone pellet‐implanted rats as compared with the release observed in the vehicle‐ Implanted control rats. Expand
Activation of corticotropin-releasing factor receptors from the basolateral or central amygdala increases the tonic immobility response in guinea pigs: An innate fear behavior
TLDR
Data suggest that the activation of the CRF receptors in the BLA or the CeA probably potentiates fear and anxiety, which may be one of the factors that promote an increase in the TI behavior. Expand
Does amygdaloid corticotropin‐releasing hormone (CRH) mediate anxiety‐like behaviors? Dissociation of anxiogenic effects and CRH release
TLDR
While neural circuits involving CRH and/or glutamatergic receptors at the CeA may be activated by an unfamiliar environment, the data challenge the view that activation of these receptors is necessary for the expression of anxiety‐like behavioral responses. Expand
Effects of intracerebral ventricular administration of gastrin-releasing peptide and its receptor antagonist RC-3095 on learned fear responses in the rat
TLDR
The role(s) of GRP and its receptor antagonist (D-Tpi6, Leu13 psi[CH2NH]-Leu14) BB((6-14)) (RC-3095) in fear-related responses using two animal models of conditioned fear are characterized to provide further evidence that GRP is involved in conditioned fear responses. Expand
Activation of gastrin-releasing peptide receptors at the infralimbic cortex elicits gastrin-releasing peptide release at the basolateral amygdala: Implications for conditioned fear
TLDR
The finding that the release profile of GRP was similar following administration of either GRP or its receptor antagonist, lends support to the view that RC-3095 has partial agonist properties, and provides further evidence for the involvement ofGRP in fear and anxiety-related disorders. Expand
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