Aversive Pavlovian Control of Instrumental Behavior in Humans

@article{Geurts2013AversivePC,
  title={Aversive Pavlovian Control of Instrumental Behavior in Humans},
  author={Dirk E. M. Geurts and Quentin J. M. Huys and Hanneke E. M. den Ouden and Roshan Cools},
  journal={Journal of Cognitive Neuroscience},
  year={2013},
  volume={25},
  pages={1428-1441}
}
Adaptive behavior involves interactions between systems regulating Pavlovian and instrumental control of actions. Here, we present the first investigation of the neural mechanisms underlying aversive Pavlovian–instrumental transfer using fMRI in humans. Recent evidence indicates that these Pavlovian influences on instrumental actions are action-specific: Instrumental approach is invigorated by appetitive Pavlovian cues but inhibited by aversive Pavlovian cues. Conversely, instrumental… Expand
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References

SHOWING 1-10 OF 121 REFERENCES
Serotonin and Aversive Pavlovian Control of Instrumental Behavior in Humans
TLDR
Data suggest that serotonin is selectively involved in Pavlovian inhibition due to aversive expectations and have implications for the understanding of the mechanisms underlying a range of affective, impulsive, and aggressive neuropsychiatric disorders. Expand
Avoidance‐based human Pavlovian‐to‐instrumental transfer
TLDR
The results suggest that avoidance‐based PIT utilizes a similar neural mechanism to that seen with PIT in an appetitive context, which has implications for understanding mechanisms of drug‐seeking behavior during addiction and relapse. Expand
Medial Amygdala Lesions Selectively Block Aversive Pavlovian–Instrumental Transfer in Rats
Pavlovian conditioned stimuli (CSs) play an important role in the reinforcement and motivation of instrumental active avoidance (AA). Conditioned threats can also invigorate ongoing AA respondingExpand
Serotonin Modulates the Effects of Pavlovian Aversive Predictions on Response Vigor
TLDR
Tryptophan depletion removed the bias against responding on the punished button, and abolished slowing in the presence of punished stimuli, irrespective of response, suggesting additional specificity for the influence of 5-HT on aversively motivated behavioral inhibition. Expand
Differential representation of Pavlovian–instrumental transfer by prefrontal cortex subregions and striatum
TLDR
Findings suggest that parallel phasic activation of mPFC and OFC neuronal subsets participates in the transfer from Pavlovian incentives to instrumental actions. Expand
Disentangling the Roles of Approach, Activation and Valence in Instrumental and Pavlovian Responding
TLDR
It is found that subjects neglect losses in their instrumental learning, arguing for a view of the Pavlovian system as a constraint or prior, facilitating learning by alleviating computational costs that come with increased flexibility. Expand
The Neural Mechanisms Underlying the Influence of Pavlovian Cues on Human Decision Making
TLDR
The results suggest that choosing an action incompatible with a pavlovian-predicted outcome might require the inhibition of feasible but nonselected action–outcome associations, and are relevant for understanding how marketing actions can affect consumer choice behavior as well as for how environmental cues can influence drug-seeking behavior in addiction. Expand
The General and Outcome-Specific Forms of Pavlovian-Instrumental Transfer Are Differentially Mediated by the Nucleus Accumbens Core and Shell
TLDR
Evidence is reported of a double dissociation between general and outcome-specific PIT at the level of the accumbens, which suggests that whereas the NAC core mediates the general excitatory effects of reward-related cues, the Nac shell mediating the effect of outcome- specific reward predictions on instrumental performance, and thereby serve to clarify reported discrepancies regarding the role of the N AC core and shell in PIT. Expand
Go and no-go learning in reward and punishment: Interactions between affect and effect
TLDR
The behavioral and computational data showed that instrumental learning is contingent on overcoming inherent and plastic Pavlovian biases, while the neuronal data showed this learning is linked to unique patterns of brain activity in regions implicated in action and inhibition respectively. Expand
Opposing Effects of Appetitive and Aversive Cues on Go/No-go Behavior and Motor Excitability
TLDR
Results show that maladaptive behaviors arise from motivational cues quickly spilling over into the motor system and biasing behavior even before action selection and, second, that this occurs in opposing directions for appetitive and aversive cues. Expand
...
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