Aversion to Nicotine Is Regulated by the Balanced Activity of β4 and α5 Nicotinic Receptor Subunits in the Medial Habenula

@article{Frahm2011AversionTN,
  title={Aversion to Nicotine Is Regulated by the Balanced Activity of β4 and α5 Nicotinic Receptor Subunits in the Medial Habenula},
  author={Silke Frahm and Marta A. Ślimak and Leiron Ferrarese and Julio Santos-Torres and Beatriz Antolin-Fontes and Sebastian Auer and Sergey Yu Filkin and St{\'e}phanie Pons and Jean-Fred Fontaine and V. I. Tsetlin and Uwe Maskos and Ines Iba{\~n}ez-Tallon},
  journal={Neuron},
  year={2011},
  volume={70},
  pages={522-535}
}
Nicotine dependence is linked to single nucleotide polymorphisms in the CHRNB4-CHRNA3-CHRNA5 gene cluster encoding the α3β4α5 nicotinic acetylcholine receptor (nAChR). Here we show that the β4 subunit is rate limiting for receptor activity, and that current increase by β4 is maximally competed by one of the most frequent variants associated with tobacco usage (D398N in α5). We identify a β4-specific residue (S435), mapping to the intracellular vestibule of the α3β4α5 receptor in close proximity… CONTINUE READING
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