Avermectin transepithelial transport in MDR1- and MRP-transfected canine kidney monolayers

@article{Brayden2007AvermectinTT,
  title={Avermectin transepithelial transport in MDR1- and MRP-transfected canine kidney monolayers},
  author={David J. Brayden and Joanna Griffin},
  journal={Veterinary Research Communications},
  year={2007},
  volume={32},
  pages={93-106}
}
Fluxes of the anti-parasitic agents, [3H]-ivermectin, [3H]-selamectin and [3H]-moxidectin were studied across non-transfected and transfected canine kidney epithelial monolayers, MDCK II/wt, MDCK II-MDR1, MDCK II-MRP1 and MDCK II-MRP2. All four lines surprisingly expressed significant levels of P-glycoprotein (P-gp), coded for by MDR1, but MDCK II-MDR1 expressed increased levels compared to the other lines. MDCK II-MRP1 and MDCK II-MRP2 expressed increased levels of MRP1 and MRP2 respectively… 
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  • Zhaolin Chen, Taotao Ma, Jun Li
  • Biology
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
  • 2014
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