Avermectin B1a modulation of gamma-aminobutyric acid receptors in rat brain membranes.

@article{Pong1982AvermectinBM,
  title={Avermectin B1a modulation of gamma-aminobutyric acid receptors in rat brain membranes.},
  author={S S Pong and Ching C. Wang},
  journal={Journal of neurochemistry},
  year={1982},
  volume={38 2},
  pages={375-9}
}
Avermectin B1a stimulates high-affinity binding of [3H]-gamma-aminobutyric acid (GABA) to receptors in washed rat brain membranes. Scatchard analysis of the data indicates that the drug does not significantly alter the apparent dissociation constant of GABA binding, but increases the detectable number of binding sites from 3.2 to 5.1 pmol/mg protein, (+)-Bicuculline completely blocks control and avermectin B1a-stimulated GABA binding, whereas picrotoxin antagonizes specifically the avermectin… CONTINUE READING