Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case Series unselected for family history: a combined analysis of 22 studies.

@article{Antoniou2003AverageRO,
  title={Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case Series unselected for family history: a combined analysis of 22 studies.},
  author={Antonis C. Antoniou and Paul P. D. Pharoah and Steven A Narod and Harvey A. Risch and Jorunn Erla Eyfjord and J. L. Hopper and Niklas Loman and H{\aa}kan Olsson and O Johannsson and {\AA}ke Borg and Barbara Pasini and Paolo Radice and Siranoush Manoukian and Diana Eccles and Nelson Tang and Edith Ol{\'a}h and Hoda Anton-Culver and Ellen Warner and Jan A. Lubiński and Jacek Gronwald and Bohdan G{\'o}rski and Hrafn Tulinius and Steinunn Thorlacius and Hannaleena Eerola and Heli Nevanlinna and Kirsi Syrj{\"a}koski and O. P. Kallioniemi and Deborah V. Thompson and Chris Evans and Julian Peto and Fiona Lalloo and Dafydd Gareth Richard Evans and Douglas F. Easton},
  journal={American journal of human genetics},
  year={2003},
  volume={72 5},
  pages={1117-30}
}
Germline mutations in BRCA1 and BRCA2 confer high risks of breast and ovarian cancer, but the average magnitude of these risks is uncertain and may depend on the context. Estimates based on multiple-case families may be enriched for mutations of higher risk and/or other familial risk factors, whereas risk estimates from studies based on cases unselected for… CONTINUE READING