Avenues for entry of peripherally administered protein to the central nervous system in mouse, rat, and squirrel monkey.

@article{Balin1986AvenuesFE,
  title={Avenues for entry of peripherally administered protein to the central nervous system in mouse, rat, and squirrel monkey.},
  author={Brian J. Balin and R. D. Broadwell and Michael Salcman and M. El-Kalliny},
  journal={The Journal of comparative neurology},
  year={1986},
  volume={251 2},
  pages={260-80}
}
Pathways traversed by peripherally administered protein tracers for entry to the mammalian brain were investigated by light and electron microscopy. Native horseradish peroxidase (HRP) and wheat germ agglutinin (WGA) conjugated to peroxidase were administered intranasally, intravenously, or intraventricularly to mice; native HRP was delivered intranasally or intravenously to rats and squirrel monkeys. Unlike WGA-HRP, native HRP administered intranasally passed freely through intercellular… CONTINUE READING
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