Aven-mediated checkpoint kinase control regulates proliferation and resistance to chemotherapy in conventional osteosarcoma.

@article{Baranski2015AvenmediatedCK,
  title={Aven-mediated checkpoint kinase control regulates proliferation and resistance to chemotherapy in conventional osteosarcoma.},
  author={Zuzanna Baranski and Tijmen H. Booij and Anne-Marie Cleton-Jansen and Leo S. Price and Bob van de Water and Judith V M G Bov{\'e}e and P. C. W. Hogendoorn and Erik H. J. Danen},
  journal={The Journal of pathology},
  year={2015},
  volume={236 3},
  pages={348-59}
}
Conventional high-grade osteosarcoma is the most common primary bone sarcoma, with relatively high incidence in young people. In this study we found that expression of Aven correlates inversely with metastasis-free survival in osteosarcoma patients and is increased in metastases compared to primary tumours. Aven is an adaptor protein that has been implicated in anti-apoptotic signalling and serves as an oncoprotein in acute lymphoblastic leukaemia. In osteosarcoma cells, silencing Aven… CONTINUE READING
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