Avarol-induced DNA strand breakage in vitro and in Friend erythroleukemia cells.

  title={Avarol-induced DNA strand breakage in vitro and in Friend erythroleukemia cells.},
  author={Werner E. G. M{\"u}ller and Du{\vs}an M. Sladi{\'c} and Rudolf Karl Zahn and Karl H. B{\"a}ssler and Nikola P Dogovic and Hans Juergen Gerner and Miroslav J. Gasi{\'c} and Heinz C. Schr{\"o}der},
  journal={Cancer research},
  volume={47 24 Pt 1},
The hydroquinone-containing cytostatic compound avarol inhibits predominantly growth of those cell lines which have a low level of superoxide dismutase. The substrate of this enzyme, the superoxide anion, was found to be formed during the in vitro oxidation reaction of avarol to its semiquinone radical in the presence of oxygen. Under the same incubation conditions plasmid DNA (pBR322) was converted from the fully supercoiled circular form mainly to the nicked circular form, indicating that the… CONTINUE READING


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