Availability of intestinal microbial lysine for whole body lysine homeostasis in human subjects.

@article{Metges1999AvailabilityOI,
  title={Availability of intestinal microbial lysine for whole body lysine homeostasis in human subjects.},
  author={Cornelia C. Metges and Antoine E El-Khoury and Lidewij Henneman and Klaus J{\"u}rgen Petzke and Ian Grant and Shahinaze Bedri and Paulo P Pereira and Alfred M. Ajami and Malcolm F Fuller and Vernon R. Young},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={1999},
  volume={277 4},
  pages={E597-E607}
}
We have investigated whether there is a net contribution of lysine synthesized de novo by the gastrointestinal microflora to lysine homeostasis in six adults. On two separate occasions an adequate diet was given for a total of 11 days, and a 24-h (12-h fast, 12-h fed) tracer protocol was performed on the last day, in which lysine turnover, oxidation, and splanchnic uptake were measured on the basis of intravenous and oral administration ofl-[1-13C]lysine andl-[6,6-2H2]lysine, respectively… CONTINUE READING

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