Availability of activated CD4+ T cells dictates the level of viremia in naturally SIV-infected sooty mangabeys.

@article{Klatt2008AvailabilityOA,
  title={Availability of activated CD4+ T cells dictates the level of viremia in naturally SIV-infected sooty mangabeys.},
  author={Nichole R. Klatt and Francois Villinger and Pavel Bo{\vs}t{\'i}k and Shari N. Gordon and Lara Mota Pereira and Jessica C. Engram and Ann E. Mayne and Richard M. Dunham and Benton D. Lawson and Sarah J. Ratcliffe and Donald L Sodora and James Else and Keith A Reimann and Silvija I. Staprans and Ashley T Haase and Jacob D Estes and Guido Silvestri and Aftab A Ansari},
  journal={The Journal of clinical investigation},
  year={2008},
  volume={118 6},
  pages={
          2039-49
        }
}
Naturally SIV-infected sooty mangabeys (SMs) remain asymptomatic despite high virus replication. Elucidating the mechanisms underlying AIDS resistance of SIV-infected SMs may provide crucial information to better understand AIDS pathogenesis. In this study, we assessed the determinants of set-point viremia in naturally SIV-infected SMs, i.e., immune control of SIV replication versus target cell limitation. We depleted CD4+ T cells in 6 naturally SIV-infected SMs by treating with humanized anti… CONTINUE READING

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