Availability of PSC833, a substrate and inhibitor of P-glycoproteins, in various concentrations of serum.

@article{Smith1998AvailabilityOP,
  title={Availability of PSC833, a substrate and inhibitor of P-glycoproteins, in various concentrations of serum.},
  author={Alexander D. Smith and Ulrike Mayer and Alfred H Schinkel and Piet Borst},
  journal={Journal of the National Cancer Institute},
  year={1998},
  volume={90 15},
  pages={1161-6}
}
BACKGROUND P-glycoproteins are membrane-associated transporters that can render cells resistant to a variety of chemotherapeutic drugs. Reversal agents are (preferably nontoxic) drugs that can inhibit these P-glycoproteins and thereby overcome multidrug resistance. PSC833, a cyclosporin A analog, is a reversal agent that has shown potential in in vitro experiments and in clinical trials. We tested PSC833 to determine whether it is a transported substrate of human and murine P-glycoproteins… CONTINUE READING

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