Availability and applications of ATP-binding cassette (ABC) transporter blockers

  title={Availability and applications of ATP-binding cassette (ABC) transporter blockers},
  author={Alicia Ponte-Sucre},
  journal={Applied Microbiology and Biotechnology},
ATP-binding cassette (ABC) transporters encompass membrane transport proteins that couple the energy derived from ATP hydrolysis to the translocation of solutes across biological membranes. The functions of these proteins include ancient and conserved mechanisms related to nutrition and pathogenesis in bacteria, spore formation in fungi, and signal transduction, protein secretion and antigen presentation in eukaryotes. Furthermore, one of the major causes of drug resistance and chemotherapeutic… CONTINUE READING
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