• Biology, Medicine
  • Published in Nature Immunology 2006
  • DOI:10.1038/ni1361

Auxiliary splice factor U2AF26 and transcription factor Gfi1 cooperate directly in regulating CD45 alternative splicing

@article{Heyd2006AuxiliarySF,
  title={Auxiliary splice factor U2AF26 and transcription factor Gfi1 cooperate directly in regulating CD45 alternative splicing},
  author={Florian Heyd and Gerdy B. ten Dam and Tarik M{\"o}r{\"o}y},
  journal={Nature Immunology},
  year={2006},
  volume={7},
  pages={859-867}
}
By alternative splicing, different isoforms of the transmembrane tyrosine phosphatase CD45 are generated that either enhance or limit T cell receptor signaling. We report here that CD45 alternative splicing is regulated by cooperative action of the splice factor U2AF26 and the transcription factor Gfi1. U2AF26 promoted formation of the less-active CD45RO by facilitating exon exclusion. Gfi1 antagonized that process by directly interacting with U2AF26, identifying a previously unknown link… CONTINUE READING

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The zinc finger transcription factor Growth factor independence 1 (Gfi1).

  • The international journal of biochemistry & cell biology
  • 2005