Auxiliary partial orthotopic liver transplantation (APOLT) in the treatment of acute liver failure

  title={Auxiliary partial orthotopic liver transplantation (APOLT) in the treatment of acute liver failure},
  author={Daniel Jaeck and Karim Boudjema and Maxime Audet and Marie-Pierre Chenard-Neu and Umberto Simeoni and Carole Meyer and Hiroshi Nakano and Philippe Wolf},
  journal={Journal of Gastroenterology},
Background. Auxiliary partial orthotopic liver transplantation (APOLT) has been developed in order to benefit from the efficacy of orthotopic liver transplantation (OLT) in the treatment of fulminant hepatic failure (FHF), but to avoid the negative counterpart of OLT which is to eliminate the possibility of native liver (NL) regeneration and which consequently implies a life-long immunosuppression.Methods. In our institution we performed 16 consecutive APOLTs in 15 patients between October 1992… 

Auxiliary Liver Transplantation

  • N. Heaton
  • Medicine, Biology
    Transplantation Surgery
  • 2019
Auxiliary liver transplantation (ALT) restores liver function in patients with severe acute liver failure, allowing time for the native liver to regenerate and if successful for subsequent withdrawal of immunosuppression, thus avoiding the risks of long-term immunos Puppression.

Auxiliary liver transplantation in children

Auxiliary liver transplants should be considered for the treatment of children with acute liver failure satisfying current criteria for liver transplantation.

Auxiliary partial liver transplantation for acute liver failure using "high risk" grafts: Case report.

The case of a 32-year-old female patient who was admitted with grade IV hepatic encephalopathy (coma) following drug-induced ALF and performed an emergency auxiliary partial orthotopic liver transplantation with a "high risk" graft (liver macrovesicular steatosis approximately 40%) from a living donor is reported.

Auxiliary transplantation for acute liver failure: Histopathological study of native liver regeneration

  • A. QuagliaB. Portmann M. Rela
  • Medicine
    Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
  • 2008
In patients undergoing ALT for ALF with a diffuse pattern of liver injury—mainly acetaminophen toxicity—hepatocyte proliferation occurs in the native liver within a few days of transplantation.

The evolution of surgical techniques in clinical liver transplantation. A review

In this review the evolution of surgical techniques in LT over the past 40 yr and their contribution to the current results are discussed.

Evidence and consequences of spectrum bias in studies of criteria for liver transplant in paracetamol hepatotoxicity.

Criteria for OLT that have a much higher positive predictive value (for death without transplant) are required, and such studies must be conducted only on those who would be considered suitable for transplant.

Modern management of acute liver failure.

Pediatric Liver Transplantation

The development of specialist care for adolescents and transition to adult services reflect the increasing numbers of long-term survivors and the emerging challenges in this population of children.



Auxiliary partial orthotopic liver transplantation (APOLT) for fulminant hepatic failure: First successful case report

The APOLT procedure indicates a new way in the treatment of fulminant hepatic failure and combines the advantages of auxiliary grafting with the disadvantages of an orthotopic normal position of the graft, thus facilitating timely decision making for indication.

Auxiliary partial orthotopic liver transplantation for Crigler-Najjar syndrome type I.

This report shows that APOLT is technically feasible and provides adequate hepatocyte mass to correct the underlying metabolic abnormality in CNS1 and provides the potential for gene therapy in the future with possible withdrawal of immunosuppression.

Auxiary Liver Transplantation For Fulminant And Subfulminant Hepatic Failure

The first series of 9 auxiliary liver transplantations performed as a bridge to recovery in 8 patients with fulminant and subfulminant hepatic failure demonstrate that auxiliary orthotopic liver transplantation is feasible in children and adults, using either a left or a right liver graft, and is efficient in providing adequate liver function.

Auxiliary partial liver transplantation for end-stage chronic liver disease.

It is concluded that auxiliary partial Liver Transplantation is an attractive alternative to orthotopic liver transplantation in high-risk patients and its role in other patients who need liver transplants remains to be defined.

Orthotopic Liver Transplantation in Fulminant and Subfulminant Hepatitis The Paul Brousse Experience

Orthotopic liver transplantation is an effective treatment in fulminant hepatitis and use of high-risk grafts permitted transplantation of 83% of patients, but was responsible for higher mortality.

Auxiliary liver transplantation: Regeneration of the native liver and outcome in 30 patients with fulminant hepatic failure–a multicenter European study

Auxiliary liver transplantation (LT) is a special procedure of LT which could be proposed to patients with fulminant hepatic failure (FHF) and has for aim that complete regeneration of the native

Auxiliary partial orthotopic living donor liver transplantation as an aid for small-for-size grafts in larger recipients.

This procedure can expand the indication of living donor liver transplants for adult recipients when the native liver retains some functional capability to support the grafted liver during the immediate postoperative period.